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Lignans and Breast Cancer Research
Lignans - breast cancer link to be studied
By Lois Baker - Contributing Editor
October 10, 2002
The role of plant-based estrogens in modifying breast-cancer risk is the subject of a five-year research study
and intervention to be conducted by nutritional epidemiologists at University of Buffalo.
The research will be funded by a $569,896 Research Career Development Award from the National Cancer Institute to
Susan McCann, research assistant professor of social and preventive medicine in the School of Medicine and Biomedical Sciences.
McCann's research will focus on one class of phytoestrogens - plant compounds with estrogen-like activityŚcalled lignans,
which are found in the cell walls of fruits, vegetables, whole grains, berries, seeds and nuts. They are the most abundant
source of plant-based estrogens in the typical American diet, and flaxseed contains the highest concentration of lignans.
Plant lignans from flaxseed have been shown to modify urinary excretion of two estrogen metabolites that have been associated
with breast-cancer risk, McCann said. Moreover, epidemiologic studies suggest that cancer risk is lower among populations with
higher intakes of lignans (measured by the amount excreted in the urine), she noted, but no studies to date have assessed the
association between breast-cancer risk and actual dietary intake of lignans.
There also is evidence that a woman's genetic makeup may affect both the quantity of phytoestrogens that are used by the body and
the way estrogens are broken down, or metabolized. The metabolic process determines the ratio of weak estrogen metabolites (thought
to lower the risk of breast cancer) to strong (thought to increase the risk).
McCann and colleagues will investigate the influence of two specific genes associated with breast-cancer risk on lignan metabolism
in a bank of blood samples collected from breast-cancer patients and controls, and compare lignan intake in the two groups, based
on dietary records provided by participants.
In addition, they will conduct a dietary intervention, using flaxseed, to assess the effect of phytoestrogen intake on estrogen
levels in healthy women, and to compare the effect of genetic variation on the effect that lignans have on estrogen levels.
Approximately 300 postmenopausal women who are not taking hormones or natural hormone supplements will be recruited for the
intervention. Participants will provide blood and urine samples at the start of the study, consume about one tablespoon of ground
flaxseed with their regular diet for seven days, and then provide another set of blood and urine samples. Participants also will
complete questionnaires about their health, medical and reproductive history, diet and other health habits.
McCann hypothesizes that the analysis of the banked blood samples' high intake of lignans will be associated with a decreased risk
of breast cancer, independent of other non-dietary risk factors, and that the extent of this protective effect will depend upon a
woman's genetic make-up.
In the intervention study, she expects to find that lignan supplementation will modify serum concentrations of certain estrogen
metabolites and the ratio of weak to strong estrogen metabolites, and that this ratio also will be affected by genotype.
In the final analysis, McCann said she hopes to show that consumption of foods high in lignans can help protect women from
developing breast cancer.
Next page - Individual Risk Factors?
See below for a sample of Fortified Flax Hulls (1st pic) and Flax Hulls (2nd pic)
Each jar contains 180gm of fortified flax hulls or 150gm of flax hulls
The above information is provided for general
educational purposes only. It is not intended to replace competent
health care advice received from a knowledgeable healthcare professional.
You are urged to seek healthcare advice for the treatment of any
illness or disease.
Health Canada and the FDA (USA) have not evaluated these
statements. This product is not intended to diagnose, treat, cure, or prevent