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Lignans and Prostate Cancer Research
Effect of flaxseed supplementation on prostatic
carcinoma in transgenic mice.
Reference - Lin X, Gingrich JR, Bao W, Li J, Demark-Wahnefried W.
Division of Urologic Surgery, Department of Surgery, and Center for Aging and Human Development,
Duke University Medical Center, Durham, North Carolina 27710, USA.
Urology. 2002 Nov;60(5):919-24.
To investigate the effects of flaxseed supplementation on prostatic neoplasia in the transgenic
adenocarcinoma mouse prostate (TRAMP) model.
A total of 135 male TRAMP mice 5 to 6 weeks old were randomized to a control group (AIN-76A diet) or
an experimental group (AIN-76A diet plus 5% flaxseed by weight). One half of the mice in each group
were treated for 20 weeks and the remainder for 30 weeks. At autopsy, urogenital tissues (four prostatic
lobes, seminal vesicles, and emptied bladder), lungs, lymph nodes, and grossly abnormal tissues were
collected for histologic evaluation.
Of the control mice, 100% developed prostate cancer versus 97% of the mice in the flaxseed group. The
tumor/urogenital weight was 3.6 +/- 0.4 g in the controls versus 1.9 +/- 0.2 g in the flaxseed-treated
mice (P = 0.0005). At 20 weeks, no significant difference in tumor grade was seen between the two groups;
however, at 30 weeks, the flaxseed-treated mice had significantly less aggressive tumors than did the
controls (P = 0.01). The prevalence of lung and lymph node metastases was 13% and 16%, respectively, in
the control mice versus 5% and 12%, respectively, in the experimental group (difference not significant).
After 20 weeks of treatment, cellular proliferation (Ki-67) differed significantly between the control and
experimental groups (38.1 +/- 2.03 versus 26.2 +/- 2.03; P less than 0.0001), and the apoptotic index
(deoxynucleotidyl transferase-mediated dUTP-digoxigenin nick end labeling) was 1.45 +/- 0.14 versus 3.3 +/- 0.31
(P less than 0.0001). Similar differences were seen after 30 weeks of treatment.
A diet supplemented with 5% flaxseed inhibits the growth and development of prostate cancer in the TRAMP model.
Next Page - Flax's Ability to Prevent Prostate Cancer
See below for a sample of Fortified Flax Hulls (1st pic) and Flax Hulls (2nd pic)
Each jar contains 180gm of fortified flax hulls or 150gm of flax hulls
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educational purposes only. It is not intended to replace competent
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You are urged to seek healthcare advice for the treatment of any
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Health Canada and the FDA (USA) have not evaluated these
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